Ototoxic effects from gentamicin ear drops.
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چکیده
منابع مشابه
Aminoglycoside-Induced Hair Cell Death of Inner Ear Organs Causes Functional Deficits in Adult Zebrafish (Danio rerio)
Aminoglycoside antibiotics, like gentamicin, kill inner ear sensory hair cells in a variety of species including chickens, mice, and humans. The zebrafish (Danio rerio) has been used to study hair cell cytotoxicity in the lateral line organs of larval and adult animals. Little is known about whether aminoglycosides kill the hair cells within the inner ear of adult zebrafish. We report here the ...
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Gentamicin sulphate is used clinically to produce vestibular organ damage in patients with intractable vertigo. The drug is given locally by middle ear instillation. In humans, gentamicin appears to have a more toxic effect on the vestibular parts of the inner ear than on the cochlea. However, cochlear effects are not insignificant and to further explore the utility of monitoring vestibular and...
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Ototoxicity is a significant side effect of a number of drugs, including the aminoglycoside antibiotics and platinum-based chemotherapeutic agents that are used to treat life-threatening illnesses. Although much progress has been made, the mechanisms that lead to ototoxic loss of inner ear sensory hair cells (HCs) remains incompletely understood. Given the critical role of protein phosphorylati...
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Freeze-fracture has been used to examine the effects of gentamicin on membrane structure in liposomes of different anionic phospholipids combined with a neutral phospholipid, phosphatidylcholine. The molar ratios of neutral: anionic lipid were 1:1 (high anionic lipid ratio) and 4:1 (low anionic lipid) and the liposomes were incubated with 0.1 mM (low) and 1 mM (high) gentamicin. With the anioni...
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BACKGROUND Chronic suppurative otitis media (CSOM) is a disease well-known for its recurrence and persistence despite treatment. The situation is compounded by the increasing resistance to antimicrobial agents by bacteria these days. AIM This study was carried out to examine the current local bacteriological profile of CSOM and to compare the profile of either ear in bilaterally discharging e...
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عنوان ژورنال:
- CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
دوره 167 1 شماره
صفحات -
تاریخ انتشار 2002